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Positive impact of hepatitis C virus (HCV) treatment on antiretroviral treatment adherence in human immunodeficiency virus-HCV coinfected patients: one more argument for expanded access to HCV treatment for injecting drug users.

 
Type de document
Articles dans des revues scientifiques
Titre original du chapitre
Positive impact of hepatitis C virus (HCV) treatment on antiretroviral treatment adherence in human immunodeficiency virus-HCV coinfected patients: one more argument for expanded access to HCV treatment for injecting drug users.
Auteurs physiques
Roux, P., Fugon, L., Winnock, M., Salmon-Ceron, D., Lacombe, K., Sogni, P., Spire, B., Dabis, F., Carrieri, M. P.
Auteurs collectifs
ANRS-CO-13-HEPAVIH Study Group.
Date d'édition
2012
Revue
Addiction ; 107 , 1 : 152-9. doi: 10.1111/j.1360-0443.2011.03608.x.PMID:21819472
Résumé du document en anglais
AIMS: Treatment for the hepatitis C virus (HCV) may be delayed significantly in human immunodeficiency virus (HIV)/HCV coinfected patients on antiretroviral treatment (ART) for fear that its burden could compromise ART adherence. However, the effect such treatment has on ART adherence in observational settings remains largely unknown. Longitudinal data were used to investigate the relationship between initiating HCV treatment and adherence to ART in HIV/HCV coinfected patients.

DESIGN: The French national prospective cohort of patients coinfected with HIV and HCV (ANRS-CO-13-HEPAVIH) is a multi-centre cohort.

SETTING: Seventeen out-patient hospital services delivering HIV and HCV care in France.

PARTICIPANTS: HIV/HCV coinfected patients on ART (n = 593 patients, 976 visits).

MEASUREMENTS: Self-administered questionnaires and medical records. A mixed logistic regression model based on generalized estimates equations (GEE) to identify factors associated with non-adherence to ART.

FINDINGS: Among the 593 patients, 36% were classified as non-adherent to ART at the enrolment visit and 12% started HCV treatment during follow-up. ART adherence was not associated statistically with HCV treatment initiation. The proportion of patients maintaining adherence or becoming adherent to ART for those starting HCV treatment was higher than in the rest of the sample (P = 0.07). After multiple adjustment for known correlates, such as poor housing conditions, binge drinking, recent drug use and depressive symptoms, patients who initiated HCV treatment were less likely to be non-adherent to ART [odds ratio (95% confidence interval) = 0.41 (0.24-0.71)].

CONCLUSIONS: Engaging human immunodeficiency virus/hepatitis C virus coinfected individuals in hepatitis C virus treatment is associated with high adherence to antiretroviral treatment. Physicians should prioritize hepatitis C virus treatment as part of a multi-disciplinary approach.

Code bibliographique
12_S58
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